In this issue:
What do heavy periods and bone loss have in common?    Back to Top

Vitamin K is the answer. Vitamin K is involved in blood clotting, bone strength, enhancing the immune system and it also promotes heart health.

Vitamin K2 is a newly available extract of natto that provides the highly bioavailable form of vitamin K2 as menaquinone MK-7.

Half of the vitamin K our body absorbs is from green leafy vegetables. Unfortunately, it turns out that most foods thought to be rich in vitamin K have less vitamin K than previously thought. Most multi-vitamins don't even contain vitamin K and the ones that do don't have enough.

An ancient Japanese food called natto is the best natural source of vitamin K2. The highest amounts of vitamin K are found in fermented foods such as natto. Adding fermented foods to your diet is necessary to reap the health benefits of vitamin K.

Vitamin K2 MK-7 and Bone Health
There have been several studies that confirm the effectiveness of vitamin K in bone health. Studies show that calcium in the bones and arteries is regulated by vitamin K. Vitamin K has been associated with osteoblasts. Osteoblasts are cells that build bone and produce a protein called osteocalcin. Osteocalcin is a protein like glue that incorporates calcium into the bones. Without vitamin K2, osteocalcin cannot be produced in the body. Proteins can't hold onto calcium without enough vitamin K. Without a functioning protein to control calcium, it can drift out of the bones and into arteries and other soft tissues, but vitamin K2 redirects the calcium into bones.

Vitamin K2 MK-7 and Heart Health
Studies have shown that an adequate intake of vitamin K2 helps to reduce the risk of coronary heart disease. In one population-based study, it was found that those who supplemented with adequate amounts of vitamin K2 had a lower risk of aortic calcification and coronary heart disease than those who supplemented with vitamin K1. The vitamin K2 found in this formula is the most concentrated, health-promoting form of this vitamin available.

Vitamin K2 and Blood Clotting
"K" in vitamin K comes from the German word koagulation. Vitamin K2 plays an essential role in blood clotting. Deficiencies can lead to nose bleeds, easy bruising and extremely heavy menstrual bleeding (menorrhagia). It is important to take vitamin K2 with ESTROSMART to help alleviate heavy periods.

Advantages of Vitamin K2 MK-7 over other forms of Vitamin K
  1. 10 times more absorption than other forms of Vitamin K and it is not bound to fibre (like Vitamin K1)
  2. Regulates calcium in blood vessels to promote bone health
  3. MK-7 creates probiotics in the gastrointestinal system
  4. Non-animal sourced and suitable for vegetarians/vegans
  5. Non-GMO manufacturing and ingredients
  6. Not derived from nicotine like other forms of Vitamin K2
Use 200mcg of MK-7 Vitamin K2 daily with meals.

Estriol for urinary incontinence    Back to Top

Bioidentical oral estrogen supplements typically consist of estriol alone or estriol in combination with smaller percentages of the stronger estrogens. Examples include Tri-Est, which is most often prescribed as 80 percent estriol, 10 percent estradiol, and 10 percent estrone or Bi-Est, which is 80 percent estriol, with 20 percent estradiol. Bi-Est and Tri-Est are also available in transdermal form, which is the delivery system that we prefer in most cases. In Clinical Obstetrics and Gynecology in 2001, Dr. Maida Taylor published a review article, called Unconventional Estrogens, Estriol, Bi-Est and Tri-Est, in which she evaluated all the research at that time on bioidentical hormones. Her conclusions were that they appeared safer but should be monitored by a physician and given in appropriate dosages. No controlled trials of Bi-est and Tri-est have been performed at the time of writing this eletter and my new book Sexy Hormones. On the other hand, estriol, the major component of Bi-Est and Tri-Est, has many good studies showing its positive effects, especially for mitigating urinary incontinence and vaginal dryness and thinning.

Estriol's unique, and perhaps most important, role still being explored is to oppose the growth of cancer cells, including cancer promoted by its more potent sisters, estrone and estradiol.

We know estriol plays far more than just a defensive role. In Europe, estriol has been used for over four decades to successfully treat hot flashes, night sweats, thinning of the vaginal wall, and urinary problems. And estriol is heavily researched as a topical face cream for wrinkles in Europe. Vaginal estriol is without these risks.

Bioidentical Estriol for Hot Flashes: In one major trial, 22 practicing gynecologists from 11 large hospitals in Germany treated 911 perimenopausal women with bioidentical estriol and evaluated them regularly for 5 years. They found this form of estriol to be extremely effective for common menopausal symptoms. No significant side effects were reported, and no thickening of the endometrial lining of the uterus was noted upon annual biopsy.

Bioidentical Estriol for Urinary Incontinence: Another Swedish study of 40 postmenopausal women with urinary incontinence for up to a decade had a 75 percent improvement with vaginal bioidentical estriol treatment. Eight of the participants who had lost the ability to regulate their urination returned to normal. Think of the number of women suffering with urinary incontinence who could be helped with bioidentical vaginal estriol.

Bioidentical Estriol for Bone Density: Japanese studies using bioidentical estriol to improve bone density have shown a positive effect, which may be due to diet and/or genetics because studies with conflicting results have been published in the U.S. The more potent bioidentical estradiol reduces postmenopausal bone loss. Because Bi-Est and Tri-Est each contain a combination of estriol with estradiol, it is possible that these formulations will have positive effects on bone, but it has not been researched yet.

Bioidentical Estriol Counters Strong Estrogens: Bioidentical estriol, in normal, low doses does not cause proliferation of the endometrial lining and does not cause proliferation of breast tissue. It also blocks and counters the action of the stronger estradiol and estrone. Estriol in oral form would have to be taken in double the dose of estradiol or synthetic estrogens to cause proliferation of the lining of the uterus.

Further research shows that the best use of bioidentical estriol is in combination with natural progesterone.

Estriol is the estrogen that is most beneficial to the vagina, cervix, and vulva. In cases of vaginal dryness and atrophy, which predispose a woman to vaginitis and cystitis, topical estriol is the most effective and safest estrogen to use. Estriol is recommended for the treatment of urinary tract infections and urinary incontinence and leakage.

In an open, multi-center, controlled study, 629 women suffering from stress and urgency urinary incontinence were treated with vaginally administered estriol at a dose of 1.0 mg daily for three weeks, and 1.0 mg bi-weekly for a further three weeks. All data for 552 of the patients were available at follow-up after six weeks of treatment. Up to an 82 percent improvement in symptoms of stress urinary incontinence was noted. Voluntary urinary control and symptoms of urgency were improved in more than 80 percent of patients. Frequency was reduced in almost 50 percent. Vaginal lubrication was improved in 77 percent of patients, and painful intercourse was no longer present in 88 percent. Vaginal atrophy improved in approximately 40 percent of cases. A quality of life score revealed an overall improvement in 72 percent of women.

Prescription:
The recommended dosage for intra-vaginal estriol is 0.5 mg to 1 mg once daily for three weeks, with 0.5 mg to 1 mg once weekly for six months. If you use this treatment, you should be examined to determine if vaginal atrophy is improving. If it has improved, you can discontinue use of estriol or use it 0.5 mg to 1 mg once every other week for another six months.

Always take any hormones, the pill, or any other hormones including estriol with ESTROSMART 2 capsules daily at breakfast to ensure your hormones stay on the correct pathway in the body and to protect you from any possible negative effects. Read my newest book Sexy Hormones coauthored with Dr. Alvin Pettle, MD for everything you need to know about hormone therapies.