IN THIS ISSUE:
Ibuprofen Linked to Breast Cancer
A Blood Test to Determine Heart Attack Risk
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Ibuprofen Linked to Breast Cancer Back to Top
A new study published on June 1 in the Journal of the National Cancer Institute, suggests that Ibuprofen, one of the most widely used painkillers, raises the risk of breast cancer. The study found that women taking the drug on a daily long-term basis had a significantly increased risk of contracting breast cancer.
The research followed more than 114,000 Californian women aged 22-85, all of them free from breast cancer at the start of the trials. All were asked to give details of the pills and medicines they consumed. During the six-year study period 2,391 of the women contracted breast cancer. They estimate that in perhaps a few dozen of the cancer cases Ibuprofen use may have played a part.
I am not surprised by the results of this study. We know that NSAIDS cause liver problems and the liver is the key organ for hormone metabolism in the body. NSAIDS also inhibit the CP450 enzyme system. This system ensures that toxins that contribute to increased breast cancer are detoxified and when it is disrupted our risk of breast cancer increases. The development of breast cancer is closely linked to hormone levels and their fluctuations, which can be affected by a range of drugs, environmental hormones and toxins.
With all the concerns surrounding the COX-2 inhibitor medications and now Ibuprofen many people are looking for safe alternatives. Read Get a Grip on Arthritis and Other Inflammatory Disorders on alternatives to NSAIDS and Acetaminophen.
A Blood Test to Determine Heart Attack Risk Back to Top
Heart disease, especially clogged arteries, was thought to be a result of too much LDL (bad cholesterol) sticking to artery walls. Yet half of those who have a heart attack have normal cholesterol levels. The Physician's Health Study, which looked at CRP levels in 22,000 healthy men and their risk of heart disease, found that there is a direct correlation between inflammation and heart disease. How can this be? In the case of heart disease and inflammation, scientists have learned that even in those with normal blood cholesterol, cholesterol can find its way into the lining of the artery and embed itself as plaque. Cells of the immune system (Macrophages) are alerted to the foreign invader and they arrive with other immune cells to eliminate the plaque. These cells bombard the site and the cholesterol plaque is broken away from the artery wall. If the plaque is big enough, it creates a blockage and then a heart attack or stroke may ensue. Women on hormone replacement therapy have to be particularly careful because estrogen increases inflammation in the body and elevates CRP to dangerous levels, indicating a much higher risk of heart attack and, particularly, strokes.
C-reactive protein is a substance produced by the liver during an inflammatory response. Dr. Paul Ridker, a cardiologist at Brigham and Women's Hospital, is the scientist who discovered that people who had elevated levels of C-reactive protein (CRP) were at higher risk of heart attack. In fact, those with hs-CRP levels above 3.0 mg/L had a risk of heart attack or stroke three times higher than the risk of those with a reading of less than 0.5 mg/L.
CRP Blood Levels
A high-sensitivity hs-CRP blood test will indicate the extent to which an individual is inflamed.
- Optimal: Less than 0.5 mg/L to 1.0 mg/L
- Should be monitored: Between 1.0 mg/L and 3.0 mg/L
- Indicates high levels of inflammation: Over 3.0 mg/L
This blood test may save your life. So many people believe that if they have normal cholesterol and blood pressure they are not at risk of heart attack. Yet 50 percent of those that have a heart attack have normal blood pressure and cholesterol. Ask your doctor for a hs-CRP test.
Letters Back to Top
I really appreciate you taking the time to provide the additional information. I picked up Get a Grip on Arthritis as soon as it was available (I actually purchased 8 extra copies to give to family and friends). Thanks to your books and seeing you several times on Fanny Kiefer and Vicky Gabereau (Body Smart Natural Diet and Get a Grip), I luckily knew about CRP and made a point of having mine tested. It's a good thing that I did! In addition to my high CRP, I have high homocysteine (12.1) and a genetic blood disorder that puts me at a ridiculously high risk of blot clots. I am addressing the elevated homocysteine with vitamin therapy - B6 (P5P form) 100 mg; B12 (sublingual methylcobalamine) 2000 mcg; folic acid 5 mg. After I read Get a Grip, I also started taking 3000 mg of pharmaceutical grade fish oil and 3 Celadrin per day.
Thanks to you, your books and your TV appearances, I have recognized that I need to make significant changes in order to avoid a disaster. My next step is to do my best with the Body Smart Natural Diet.
I really can not thank you enough for the research that you do and your willingness to share your knowledge. Not only are you improving the quality of our health but you are truly saving lives!